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hERG Screening

Published: Aug 2013 | No Of Pages: 287 | Published By: RI Technologies

This report on hERG Screening presents an in depth analysis of hERG Screening market. The study emphasizes on both technology and product segments of hERG Screening in biotechnology and pharmaceutical application areas. The report provides essential information including market data, segmentation, market size, key trends, M&A, product developments, industry forecasts, corporate intelligence, and other relevant information.

The report lists more than 120 companies that are engaged in hERG Screening services and/or production of hERG screening tools/instruments. A global perspective is presented along with regional analysis covering North America, Europe, Asia-Pacific and Rest of World. Compilation of Worldwide Patents and Research related to hERG Screening is also provided. The market is analyzed in US Dollars and includes 35 exclusive graphically illustrated exhibits.

I. SCOPE AND METHODOLOGY

II. REPORT SYNOPSIS
Introduction
Ion Channels
History
Types of Ion Channels
Voltage-Gated Ion Channel
Ligand-Gated Ion Channel
Normal Functioning of Heart
QT Interval
Short QT Syndrome
Long QT Syndrome
Types of LQTS
Genetical LQTS
Acquired LQTS
Signs and Symptoms
Drug Induced LQTS
Causes
Long QT Syndrome and Torsade de pointes
Recording the Electrical Activity of Heart Beat
Diagnosis of LQTS
Treatment
PQRST Wave
Cell Lines
HEK 293 Cell Lines
CHO or Chinese Hamster Ovary Cells
hERG and Drug Discovery
hERG Screening - Global Market Analysis
Exhibit 1. hERG Screening – Global Value Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
Exhibit 2. List of Major Global Companies

III. MARKET DYNAMICS
1. Market Overview
Global hERG Screening Market
Exhibit 3. hERG Screening – Global Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Geographic Region for North America, Europe, Asia-Pacific and Rest of World (Graphical Representation Included)
Exhibit 4. hERG Screening – Global Value Market Shares (2010, 2015 & 2020) by Geographic Region for  North America, Europe, Asia-Pacific and Rest of World (Graphical Representation Included)
The Impact of hERG
North American hERG Screening Market
Exhibit 5. hERG Screening – North American Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Country for United States and Canada (Graphical Representation Included)
Exhibit 6. hERG Screening – North American Value Market Shares (2010, 2015 & 2020) by Country for United States and Canada (Graphical Representation Included)
United States hERG Screening Market
Canadian hERG Screening Market
Exhibit 7. List of Major North American hERG Screening Companies
European hERG Screening Market
Exhibit 8. hERG Screening – European Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Country for United Kingdom, Germany, France, Switzerland, Russia and Rest of Europe (Graphical Representation Included)
Exhibit 9. hERG Screening – European Value Market Shares (2010, 2015 & 2020) by Country for United Kingdom, Germany, France, Switzerland, Russia and Rest of Europe (Graphical Representation Included)
UK hERG Screening Market
German hERG Screening Market
French HERG Screening Market
Swiss hERG Screening Market
Russian hERG Screening Market
Exhibit 10. List of Major European hERG Screening Companies
Asia-Pacific hERG Screening Market
Exhibit 11. hERG Screening – Asia-Pacific Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Country for Australia, China, India, Japan, South Korea and Rest of Asia-Pacific (Graphical Representation Included)
Exhibit 12. hERG Screening – Asia-Pacific Value Market Shares (2010, 2015 & 2020) by Country for Australia, China, India, Japan, South Korea and Rest of Asia-Pacific (Graphical Representation Included)
Australian hERG Screening Market
Chinese hERG Screening Market
Indian hERG Screening Market
Japanese hERG Screening Market
South Korean hERG Screening Market
Exhibit 13. List of Major Asia-Pacific hERG Screening Companies
Rest of World hERG Screening Market
Exhibit 14. hERG Screening – Rest of World Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Israel, South Africa, Brazil and Other Countries (Graphical Representation Included)
Exhibit 15. hERG Screening – Rest of World Value Market Share (2010, 2015 & 2020) by Israel, South Africa, Brazil and Other Countries (Graphical Representation Included)
Israeli hERG Screening Market
South Africa hERG Screening Market
Brazilian hERG Screening Market
2. Company Profiles - Major Players in hERG Screening Market
Abcam PLC (UK)
Abnova Corporation (Taiwan)
Aurora Biomed, Inc. (Canada)
AVIVA BioSciences Corporation (USA)
B’SYS GmbH (Switzerland)
Cellular Dynamics International, Inc. (USA)
Cerep SA (France)
ChanTest Corporation (USA)
Charles River Laboratories International, Inc. (USA)
More…
3. Major Activities in hERG Screening Market
ChanTest Commences a Project, Funded by US FDA’s Center for Tobacco Products (CTP)
Eurofins Panlabs Signs an Agreement with GE to Reinforce Drug Discovery Services
Molecular Devices to Supply Fluxion's IonFlux Automated Electrophysiology Systems and Associated Products Globally
ChanTest Releases the CardioChannelGram™ and SaVety Assessment
Aptuit Provides Electrophysiological Technology Platforms
More…
4. Technology Comparison
Patch Clamp Technology
Exhibit 16. Patch Clamp Technology - Estimated Market Value by Company in US$ Million for 2011 (Graphical Representation Included)
Exhibit 17. Patch Clamp Technology - Estimated Value Market Shares by Company for 2011 (Graphical Representation Included)
hERG Screening Assays
Exhibit 18. hERG Screening Assays - Estimated Market Value by Company in US$ Million for 2011 (Graphical Representation Included)
Exhibit 19. hERG Screening Assays - Estimated Market Shares by Company for 2011 (Graphical Representation Included)
hERG Screening Antibodies & Cell Lines
Exhibit 20. hERG Screening Antibodies and Cell Lines - Estimated Market Value by Company in US$ Million for 2011 (Graphical Representation Included)
Exhibit 21. hERG Screening Antibodies and Cell Lines - Estimated Market Shares by Company for 2011 (Graphical Representation Included)
5. hERG Screening - Market Outlook

IV. PRODUCT/TECHNOLOGY RESEARCH
Introduction
Channelopathies
Ion Channel Safety Pharmacology
Ion Channels as Pharmaceutical Targets
What makes ion channels attractive targets for drug development?
Patch-Clamp: The Gold Standard
Ion Channels
Basic Features of Ion Channel
Biological Role
Diseases Related to Ion Channels
Exhibit 22. Diseases Involving Ion Channel Function
Ion Channel Genes of the Human Genome
Technologies for Ion Channel Characterization
Towards Ion Channel Drug Discovery and Development
Physiological Significance of Ion Channels
Flux Assays in Ion Channel Screening
Types of Ion Channels
Voltage-Gated Ion Channel
Structure
Exhibit 23. List of Known Human Voltage-Gated Potassium Channel Alpha Subunits
Exhibit 24. List of Voltage-Gated Potassium Channel Beta Subunits
Mechanism
hERG Potassium Channel Activators and Blockers
hERG Channel Gating
hERG Channel Structure
Mechanisms of Action of Facilitators and Activators of hERG Current
Type 1 Activators
Type 2 Activators
Ligand-Gated Ion Channel
Introduction
Regulation
Clinical Relevance
hERG
Role of hERG Blockers in Cardiac Disorders
Characteristics and Clinical Applications of Cardiac hERG/I (Kr) Potassium Channel
Biophysical Properties and Molecular Determinants of Ziprasidone and its Role in Block Opening hERG
Cell Lines
HEK 293 Cell Lines
History
Application of HEK 293 Cells
CHO or Chinese Hamster Ovary Cells
hERG T-REx™ CHO Cells
Role of Potassium, Magnesium and Calcium in Normal Functioning of Heart
Magnesium
Calcium
Potassium
Membrane Potential
Improper Membrane Potential
Description
Task in Human Well Being
Common Abnormalities and Ailments
Atrial Arrhythmias
Ventricular Arrhythmias:
Arrhythmias Arising Because of Abnormalities in the AV node, Purkinje fibers, or Bundle of His
Functioning of Heart
Cardiac Phase
Electrocardiogram (EKG or ECG)
History
QRS Complex
T Wave
Abnormality in Potassium Ion Channel
Torsades de Pointes: a Cardiac Arrhythmia
Characteristics of TdP
Causes of TdP
Risk factors for TdP
Treatment
QT Interval
Short QT Syndrome
Long QT Syndrome
LQTS – The Causes
LQTS - Risks
LQTS – Signs and Symptoms
Screening and Diagnostic Procedures
Complications
LQTS - Treatment
Medical Devices and Surgical Procedures
Clinical Trials
Prevention
Self-Care
Coping Skills
Lifestyle Changes
LQTS – The Types
Inherited Long QT Syndrome
Exhibit 25. Drugs to be Avoided by Congenital QT Patients
Exhibit 26. Drugs (Withdrawn from Market) (Avoided by Congenital QT Patients)
Genetic Basis of LQTS
LQTS Associated Syndromes
Precautions
Acquired Long QT syndrome
Exhibit 27. Drugs which Block the hERG Channel
Co-Factors of Drug Induced LQTS
Symptoms for identification of drug induced LQTS
High Probability of Drug Induced LQTS
Symptoms:
Suspected Cases of Drug Induced LQTS
Symptoms:
Unlikely Case of Drug Induced LQTS
Symptoms:
1. Patch Clamp Technique
Methodology
Technique Configurations
On-Cell
Inside Out
Whole-Cell
Outside Out
Perforated whole-Cell
The Patch Clamp Technique Application
QPatch 16
QPatch HT
Q Patch Applications
QPATCH HT: Effective Application in Ion Channel Drug Discovery
Screening Station
Plates
The Q Plate Technique
Q Plate Prospects
Cell Preparation Unit
Liquid Handling System
Touch Screen
Data Acquisition
Q Patch Software
2. hERG Screening in Drug Discovery
Action from Drug Approving Authorities
Exhibit 28. Drugs (Discontinued in the Market) which Block the hERG Channel
In silico Modeling in hERG Channel Blockers
hERG Channel Archetypes and Pharmacophores
Testing In Silico for hERG K+ Channel Blockers
In Silico Categorization of hERG Channel Blockers: a Skill-Based Strategy
hERG Screening – Drugs Banned
Exhibit 29. List of Banned Drugs for Inducing LQTS
hERG and Obesity
3. Product Trends
The GLP hERG Channel Assay
Benefits Attributed to the Use of CDI Services
ICR 8000 – The latest Entrant in the Ion Channel Technology
There are vast applications of ICR 8000:
Applications of ICR 8000
Features and Parameters of ICR 8000
Uses:
ICR 12000
ICR 12000 – An advanced version of Ion Channel Technology considered ideal for hERG channel assays
Features and Parameters of ICR 12000
Rubidium Flux Assay
IonWorks® HT in hERG Channel Screening
Measurement of hERG Channel Currents Using IonWorks HT System
Sophion’s Q Patch:
QPatch 16
QPatch HT
Cell Lines in hERG Screening
Exhibit 30. List of hERG Screening Products/Technologies/Services by Company
4. Research Briefs
Sequence and Structure Specific Elements of hERG mRNA Regulate Channel Synthesis and Trafficking Efficacy
Ketamine Blocks hERG related Gene Potassium Channel
Controlling the hERG Channel by Rab4 by neural Precursor Cell-expressed developmentally down regulated Protein (4-2 (Nedd 4-2)
Do hERG Channel Inhibitors also Induce Phospholipidosis?
Cataloging Molecules for their hERG Liability
Restoration of hERG Channels in Micro Fabricated Silicon Chips
More…

V. CORPORATE DIRECTORY

VI. PATENTS INFORMATION

Exhibit 1. hERG Screening – Global Value Market Estimations & Predictions (2005 - 2020) in US$ Million (Graphical Representation Included)
Exhibit 2. List of Major Global Companies
Exhibit 3. hERG Screening – Global Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Geographic Region for North America, Europe, Asia-Pacific and Rest of World (Graphical Representation Included)
Exhibit 4. hERG Screening – Global Value Market Shares (2010, 2015 & 2020) by Geographic Region for  North America, Europe, Asia-Pacific and Rest of World (Graphical Representation Included)
Exhibit 5. hERG Screening – North American Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Country for United States and Canada (Graphical Representation Included)
Exhibit 6. hERG Screening – North American Value Market Shares (2010, 2015 & 2020) by Country for United States and Canada (Graphical Representation Included)
Exhibit 7. List of Major North American hERG Screening Companies
Exhibit 8. hERG Screening – European Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Country for United Kingdom, Germany, France, Switzerland, Russia and Rest of Europe (Graphical Representation Included)
Exhibit 9. hERG Screening – European Value Market Shares (2010, 2015 & 2020) by Country for United Kingdom, Germany, France, Switzerland, Russia and Rest of Europe (Graphical Representation Included)
Exhibit 10. List of Major European hERG Screening Companies
Exhibit 11. hERG Screening – Asia-Pacific Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Country for Australia, China, India, Japan, South Korea and Rest of Asia-Pacific (Graphical Representation Included)
Exhibit 12. hERG Screening – Asia-Pacific Value Market Shares (2010, 2015 & 2020) by Country for Australia, China, India, Japan, South Korea and Rest of Asia-Pacific (Graphical Representation Included)
Exhibit 13. List of Major Asia-Pacific hERG Screening Companies
Exhibit 14. hERG Screening – Rest of World Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Israel, South Africa, Brazil and Other Countries (Graphical Representation Included)
Exhibit 15. hERG Screening – Rest of World Value Market Share (2010, 2015 & 2020) by Israel, South Africa, Brazil and Other Countries (Graphical Representation Included)
Exhibit 16. Patch Clamp Technology - Estimated Market Value by Company in US$ Million for 2011 (Graphical Representation Included)
Exhibit 17. Patch Clamp Technology - Estimated Value Market Shares by Company for 2011 (Graphical Representation Included)
Exhibit 18. hERG Screening Assays - Estimated Market Value by Company in US$ Million for 2011 (Graphical Representation Included)
Exhibit 19. hERG Screening Assays - Estimated Market Shares by Company for 2011 (Graphical Representation Included)
Exhibit 20. hERG Screening Antibodies and Cell Lines - Estimated Market Value by Company in US$ Million for 2011 (Graphical Representation Included)
Exhibit 21. hERG Screening Antibodies and Cell Lines - Estimated Market Shares by Company for 2011 (Graphical Representation Included)
Exhibit 22. Diseases Involving Ion Channel Function
Exhibit 23. List of Known Human Voltage-Gated Potassium Channel Alpha Subunits
Exhibit 24. List of Voltage-Gated Potassium Channel Beta Subunits
Exhibit 25. Drugs to be Avoided by Congenital QT Patients
Exhibit 26. Drugs (Withdrawn from Market) (Avoided by Congenital QT Patients)
Exhibit 27. Drugs which Block the hERG Channel
Exhibit 28. Drugs (Discontinued in the Market) which Block the hERG Channel
Exhibit 29. List of Banned Drugs for Inducing LQTS
Exhibit 30. List of hERG Screening Products/Technologies/Services by Company

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