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Stem Cell Research Products: Opportunities, Tools & Technologies

Published: May 2014 | No Of Pages: 155 | Published By: BioInformant

Product Synopsis

Stem cells are primitive cells found in all multi-cellular organisms that are characterized by self-renewal and the capacity to differentiate into any mature cell type. 
Stem cells are still a relatively new discovery, as the first mouse embryonic stem cells were derived from embryos in 1981, but it was not until 1995 that the first successful culturing of embryonic stem cells from non-human primates occurred and not until November 1998 that a technique was developed to isolate and grow embryonic stem cells from human blastocysts. In 2006, induced pluripotent stem cells were produced for the first time from mouse cells and in 2007 they were produced from human cells. Furthermore, it was not until 2008 that the first full transplant of a human organ grown from adult stem cells was performed when a section of trachea was successfully transplanted into an adult woman in Spain. 
As of 2014, several broad categories of stem cells exist, including:
  • Embryonic stem cells, derived from blastocysts
  • Fetal stem cells, obtained from fetuses
  • Post-natal stem cells, derived from newborn tissues
  • Adult stem cells, found in adult tissues – including Hematopoietic stem cells, Mesenchymal stem cells, and Neural stem cells
  • Cord blood stem cells, isolated from umbilical tissue
  • Dental stem cells, derived from deciduous teeth
  • Induced pluripotent stem cells, reprogrammed from adult cells
  • Cancer stem cells, which give rise to clonal populations of cells that form tumors or disperse in the body
  • Animal stem cells, derived from non-human sources
The past 10 years have also witnessed the production of novel stem cell types, including piPSCs, R-NSCs, and VSELs. Together, this evidence suggests that additional types of stem cells will likely be discovered, each representing new opportunities for research product development. Clearly, laboratory research into stem cell derivation, manipulation, and application is rapidly expanding. 
To facilitate research resulting from these advances, a large and diverse stem cells products market has emerged. Large companies selling stem cell research products include Thermo Fisher Scientific (now merged with Life Technologies), BD Biosciences, EMD Millipore, Sigma Aldrich, and STEMCELL Technologies, as well as over one hundred other suppliers. 
Currently, the following product categories compose the majority of global stem cell product sales:
  • Primary antibodies to stem cell antigens
  • Bead-based stem cell separation systems
  • Fluorescent-based labeling and detection
  • Stem cell protein purification and analysis tools
  • Tools for DNA and RNA-based characterization of stem cells
  • Isolation/characterization services
  • Stem cell culture media and reagents
  • Stem cell specific growth factors and cytokines
  • Tools for stem cell gene regulation
  • Stem cell services and mechanisms for in vivo and in vitro stem cell tracking
  • Expansion/differentiation services for stem cell media and RNAi
  • Stem cell lines
Furthermore, to sell products in the stem cell market, it is critical to understand the research applications for which stem cells are being studied. One area of study is the use of stem cells to understand and treat birth disorders. However, of greater interest to researchers is the potential for use of stem cells in regenerative medicine to treat conditions ranging from diabetes, to cardiovascular disease and neurological disorders. 
Pharmaceutical companies have intense interest in the ability to use stem cells to improve drug target validation and toxicology screening. Therefore, it is important for companies interested in stem cell therapy applications to understand underlying market forces, and in particular, to consider progressive areas of stem cell research as opportunistic areas for drug and therapy development. This report presents a range of topics of interest to these companies as well, including how advances in stem research can reveal potential new drug targets, improve methods of drug delivery, and provide personalized treatment strategies. 
The key areas that account for the majority of applied stem cell research include:
  • Regenerative Medicine - Reversal of injury or disease
  • Drug Target Validation and Drug Delivery - Treatment of disease
  • Toxicology Screening - Drug safety and efficacy assessment
  • Understanding and Treatment of Birth Disorders - Natal repair
This 2014 report provides detailed information on both basic and applied stem cell research and research applications and includes an updated list of global stem cell research centers by region. 
Furthermore, it is crucial for stem cell companies to understand the funding environment that supports stem cell research. Currently, the U.S. federal government is an important, although not dominant, source of funding for stem cell research. The reason is that U.S. states are spending almost as much as the federal government on stem cell research and are actually spending more than the federal government on human embryonic stem cell (hESC) research. Private sources also contribute a huge amount of funding, with analysis of recent large gifts summing to over $1.7 billion. 
Growth in stem cell research has exploded in the past decade, and so the market to supply stem cell research products has grown to meet this huge demand. There are now over one million stem cell researchers worldwide. In addition, there were only 17 stem cell product companies as of 2006, and that has expanded to more than 100 today, a 6-fold increase. 
The two most active areas of stem cell research are mesenchymal stem cells, at 24.8% of all stem cell research, and hematopoietic stem cells, at 24.1% - thus accounting for nearly half of all stem cell research over a trailing twelve-month period. When this analysis was last conducted using data from full-year 2012 (Jan 1, 2012 – Dec 31, 2012), hematopoietic stem cell research led mesenchymal stem cell research, but that relationship has since switched, revealing an interesting preference toward mesenchymal stem cell research among the scientific community. 
Also of interest is that for the trailing-twelve months, induced pluripotent stem cell research activity represented 8.9% of global stem cell research activity. When this analysis was last conducted using full-year 2012 data (Jan 1, 2012 – Dec 31, 2012), induced pluripotent stem cell research activity represented only 4.0% of global research activity, which means that a substantial year-over-year shift has occurred. This report explores why this trend has developed and how it will continue to evolve in the coming decade. 
Not surprisingly, trend analysis reveals rapid increases in stem cell research activity over the past five years, specifically a scientific publication rate increase of 9.9% per year. 
The stem cell types with the greatest year-to-year increases in publication rates over a trailing five-year period include:
  • Mesenchymal stem cells
  • Induced pluripotent stem cells
  • Neural stem cells
While hematopoietic stem cells represent the second most active area of stem cell research, publication rates for these stem cell types have declined in recent years. Because research activity by stem cell type has shown divergent trends over the past few years, for research product companies to be successful, they will need to understand underlying trends in stem cell preferences, by cell type. 
This market intelligence report will advantageously position your company to offer competitive stem cell products to a rapidly growing, well-funded research community. 
End-User Survey of Stem Cell Scientists: 
A key element of this report is a survey of stem cell researchers, for the U.S. and worldwide. This 2014 survey reveals stem cell researcher needs, technical preferences, key factors influencing buying decisions, and more. It can be used to make effective product development decisions, create targeted marketing messages, and produce higher prospect-to-client conversion rates. 
To benefit from this lucrative product market, you need to anticipate and serve the needs of your clients, or your competitors will. 
This survey reveals critical findings that include:
  • Prevalence of Stem Cell Research by Cell Type
  • Stem Cell Product Preferences
  • Most Commonly Utilized Stem Cell Markers, by Stem Cell Type
  • Most Commonly Utilized Stem Cell Antibodies, by Stem Cell Type
  • Preferred Providers of Stem Cell Antibodies
  • And Much More
Input Sources: 
In addition, the market intelligence contained in this report was compiled using a broad range of sources, allowing the analysis to be thorough, current, and cutting-edge. The findings presented here will improve your strategic decision-making and will empower you to make smarter decisions, faster. 
These input sources include:
  • Stem Cell Grant Funding Databases (NIH database, DoD database)
  • Stem Cell Patent Databases (USPTO)
  • Stem Cell Publication Databases (PubMed, Highwire Press)
  • Stem Cell Product Launch Announcements (Trade Journals, Google News)
  • International Surveys (Electronically distributed end-user surveys)
  • And More
Furthermore, as a technology company, BioInformant employs advanced techniques for deriving market research and industry data. 
The following constitute the basis for our Research & Analysis:
  • Preliminary Research: Extensive secondary research based on preliminary market evaluations.
  • Fill-Gap Research: Selectively sampled and focused primary research as a fill-gap strategy.
  • Historic Analysis - Primary Products: Comprehensive analysis of all data for each primary product market.
  • Historic Analysis - End-user Markets: Historic analysis of all end-user industries/markets, requiring technology and market evaluations, growth projections, and market size estimation of end-user markets.
  • Historic Supply Chain/Raw Materials Analysis: Comprehensive analysis of data for each primary market segment.
  • Data Consolidation: Merging historic end-user market data to yield consolidated primary market data.
  • Cross Linking: Comparing primary market data (historic) with resulting end-user consolidated market data and calculating the variance in percentages between data sets by year.
Variance Determination: Placing a median figure for each year with a tolerance range equal to twice the variance percentage and recording the resulting numbers.
Projections: Projecting forward end-user markets based upon historic metrics, technology and market trends, and primary research from the marketplace.
Variance Factorization: Consolidation of projected end-user market data to yield derived primary market data. The data is adjusted to the historic variance determinations, as above. The resulting data is verified by confirmatory primary research.
Confirmatory Primary Research: Presenting resulting data from companies or individuals participating as research partners. Variations from derived data are adjusted to reflect primary research based consensus.
Electronically Based End-User Surveys: Distribution of electronically based end-user surveys to a panel of industry representatives working within market segment(s) of interest. Statistical filtering and analysis is performed on collected user-response data.
Summary of Findings: 
Full-year 2013 analysis determines the size of the stem cell research products market to be $3.22 billion, and the stem cell therapies market to be $3.31 billion, for a total of $6.53 billion. In addition, both markets are growing with double-digit growth. Producing stem cell research products thus represents a massive profit opportunity for research supply companies. 
Additionally, the industry insights contained in this market report will allow you to dramatically increase your profits within the stem cell sector. Key findings within the report include:
  • Charts, Timelines, and Financials for the Stem Cell Products Market
  • Breakdown of Research Activity by Application, Species, and Tissue Source
  • Geographical Assessment of Market Demand
  • Trend Data and Rate Analysis for Stem Cell Grants, Scientific Publications, and Patents
  • Market Size Determinations for Stem Cell Research Products
  • Market Size Determinations for Related Markets - Stem Cell Antibodies and Stem Cell Therapies
  • 5-Year Market Size Projections (2014-2018)
  • Competitive Environment Analysis, Including Identification of Market Leaders
  • Marketing Methods Used by Industry Participants
  • Crucial Trends and Unmet Market Needs
  • End-User Survey of Stem Cell Researchers (97 U.S. / 173 International / 19 Undefined)
  • And Much More
Producing stem cell products can involve complicated and confusing decisions, but it doesn't have to. Claim this report to reveal the current and future needs of your customer base, so you can focus your marketing efforts on the most profitable products, in the most promising research areas and within the most lucrative domestic and international markets. 
Staying ahead of a hungry and fast moving pack of competitors requires the very best market insights. 
So let’s get straight to the point. 
We’re offering you access to a sophisticated market intelligence report for the stem cell research supply market. 
Whether you already supply stem cell research products or you wish to expand your product line, you’ll know just how essential and lucrative this market is. We know you want to make effective product development decisions, to sell more effectively to scientists, to generate improved revenues and take market share from your competition. 
This report – published in May 2014 – shows you how to do just that, helping you understand the prevailing market conditions and giving you guidance to strategically position and develop stem cell product lines. 
So when you choose our industry-leading market report, you’ll be gaining a competitive advantage in three core areas. 
1. Understanding what your customers are thinking 
A key component of this report is a survey of the very people you’re creating products for. The data gives you an intimate insight into the minds of hundreds of research scientists – both domestic and international – working specifically in the stem cell sector. 
This expert market intelligence allows you to more profitably focus your research and development budget. With a deeper understanding of the needs of your customers, intelligent product development is the inevitable result. This means you’ll develop more successful products and minimize your unprofitable R&D spending. 
And, with access to the latest stem cell product research, you’ll be able to take advantage of new opportunities before your competitors are even aware of them. 
2. Market to these customers more effectively 
Just as you can focus your R&D spending on products with the greatest potential, so too can you ensure your marketing dollars work harder and smarter. With the insights and depth of market data contained in this report you can position your products to maximize revenue:
  • Reduce your marketing spending
  • Improve ROI for marketing dollars spent
  • Increase response rates
By understanding the current and future needs of your customer base you can focus your marketing efforts on the most profitable products, in the most promising research areas and within the most lucrative domestic and international markets. 
3. Outmaneuver your competition (that’s the nice way to put it) 
We’re witnessing an explosion in the value of the stem cell market, and that means more and more competitors for you. 
As a forward-thinking leader, you’re not satisfied with maintaining a piece of this ballooning market – you want to dominate it. Of course, your competitors are no different and they’re planning to muscle you out of the game. 
So sitting still will leave you behind. Our report allows you to do the opposite: to take decisive action, to innovate and to lead. 
  • So avoid the shrinking revenues and squeezed margins that come from increased competition. Absorb this report and make decisions with confidence.
  • Learn the key strengths of your competitors
  • Intelligently position your products to fill gaps in the market
  • Understand crucial trends to stay ahead of your competition.
  • Tracking stem cell market trends, so you don’t have to 
We have quantified and assessed the critical trends in the stem cell marketplace, ensuring all information is up-to-date. This means you’re able to focus your product 
development and marketing activity in exactly the right place to beat your competition. We compile and analyze data from a broad range of sources, including:
  • Stem cell grant funding
  • Stem cell patents
  • Stem cell publications
  • Stem cell product launches
  • New entrants to the market
  • International surveys
Not only do we measure these trends, but we also break the data down by stem cell types. 
We are loyal to the data and year on year invest heavily in the best data mining and analysis tools. Couple this with our unrivaled knowledge of the stem cell product marketplace, and this report is a road map to your success. 
Why is this report different from others available? 
It’s quite simple. Our report does not look at the whole stem cell industry as if it was one marketplace, a mistake that every other stem cell report makes. As anyone working with stem cells knows, the stem cell market has two very distinct parts: stem cell therapies (the clinical applications of stem cells for medical purposes) and stem cell research products (the research tools and reagents that are used by scientists). 
It’s the research products market you are interested in. So this entire report is geared toward helping you achieve success in developing and marketing stem cell research products. 
What does this means for your business? 
These industry insights will allow you to dramatically increase profits in the stem cell sector. And you’ll discover a game-changing focus in your marketing and R&D budgets. 
However, a word of warning: the report alone will not change your business. But in the hands of a smart and innovative leader, this exclusive information allows you to capture a larger slice of a highly profitable market. A market that will only continue to grow. 
The better the information you have, the better the decisions you’ll make. So instead of relying only on past performance indicators and incomplete market data, gain the full picture of the stem cell product market through one insightful and up-to-date source. 
A market with a billion dollars “up for grabs” 
  • The growth in research into stem cells has exploded in the past decade. And so the market to supply stem cell research products has grown to meet this huge demand.
  • There are now over one million stem cell researchers worldwide.
  • There were 17 companies when we first started monitoring the stem cell research products market in 2004. This has risen to more than 100 companies today, a 6-fold increase.
  • Full-year 2013 analysis determines the size of the stem cell research products market (including stem cell antibodies) to be $3.22 billion, and the stem cell therapies market to be $3.31 billion, for a total of $6.53 billion.
  • The potential of stem cell research in modern medicine is truly staggering. And when the answers to some of our most challenging health problems are within reach, you can be sure this market is only going to get bigger and more attractive. This is a rapid growth industry. 
Precision Valuations, by Market Segment 
The report identifies, defines, and quantifies each market segment within the stem cell product industry, including: 
You can't accurately produce market valuations without characterizing each segment of the stem cell product market. Our specialized knowledge of the industry means you get accurate, precise valuations for every segment of the market - including the ones that matter most to your business. 
Why choose BioInformant to help you succeed? 
We could use clever marketing to persuade you to buy our report. But we know you’re smarter than that. And, we simply believe the quality and value of this report speaks for itself. 
But just in case you were in doubt, you may like to know we’re the only market intelligence company that has specifically tracked the stem cell product supply market since there was a market. We began tracking the stem cell industry in 2004 and have been consulting on stem cell product strategy since 2006. 
We have served nearly all of the leading research supply companies in the industry, including Thermo Fischer Scientific, BD Biosciences, Corning, Sigma Aldrich, GE Biosciences, Beckman Coulter, Johnson & Johnson, and many more. 
We know the stem cell industry inside and out. 
It means we understand the current and future product trends more intimately than any other company. When we say we’re a global leader in stem cell industry data, you can be sure it’s not marketing hype. 
A. Human Embryonic Stem Cells
1. Early, 5-7 days (Totipotent)
2. Gonadal Ridge, 6 months (Multipotent)
B. Fetal Stem Cells (Pluripotent)
C. Umbilical Cord Stem Cells (Multipotent)
1. Cord Blood
2. Cord Matrix (“Wharton’s Jelly”)
D. Adult Stem Cells (Multipotent)
1. Hematopoietic Stem Cells
2. Mesenchymal Stem Cells
3. Neural Stem Cells
4. Dental Stem Cells
E. Cancer Stem Cells (Multipotent)
F. Induced Pluripotent Stem Cells (iPSCs)
G. Novel Stem Cell Types
1. Neural Rosette Cells (R-NSCs)
2. Very Small Embryonic Like (VSEL) Stem Cells
H. Stimulus-Triggered Acquisition of Pluipotency (STAP) Cells [Unverified]
A. Regenerative Medicine (Cell-Based Therapies)
1. Diabetes Mellitus
2. Cardiovascular Disease
3. Neurological Disease
4. Autoimmune Disease
5. Hematopoietic Disease and Transplantation Research
6. Orthopedic Repair
7. Cancer Research
8. Birth Defect Research
B. Drug Discovery & Development
1. Assays to Aid Early Stage Discovery
2. Improved Prediction of Human Responses
3. Drug Development with Humanized Mouse Models
4. Genetically-Engineered Stem Cell Lines for Screening
5. Pluripotent Stem Cell Lines for Target Validation and Drug Screening
6. Summary – Use of Stem Cells within Drug Discovery & Development
A. Thermo Fisher Scientific (Recently Merged with Life Technologies / Includes Invitrogen Brand)
1. Stem Cell Products
a. Isolation and Characterization Products
b. Expansion and Differentiation Products
2. Collaborations
a. Invitrogen and Cellartis AB
b. Invitrogen and Novocell
c. Invitrogen and the Buck Institute
d. Life Technologies and Cellular Dynamics International
e. Life Technologies and iPS Academia Japan
f. Life Technologies and Harvard University
g. Life Technologies and DNAVEC Corporation
B. BD Biosciences
1. Stem Cell Products
a. Isolation
b. Culturing
c. Analysis
2. Collaborations: BD Biosciences and Stem Cell Technologies
A. Primary Antibodies
B. Bead-based Cell Separations Systems
C. Fluorescent-based Labeling and Detection
D. Protein Purification and Analysis Tools
1.Protein Purification
2.Stem Cell Protein Analysis
3.Quantitative Proteomics
E. DNA/RNA Based Characterization
1. Tools for DNA- and RNA-based Characterization
2. Stem Cell HLA Typing
3. Stem Cell Nucleic Acid Extraction & Purification, and Associated PCR/qRT-PCR Reagents
F. Isolation / Characterization Services
1. Stem Cell HLA Typing Services
2. Stem Cell Custom Services
3. Stem Cell Custom Antibodies
G. Stem Cell Culture Media and Reagents
H. Growth Factors and Cytokines
I. Stem Cell Gene Regulation
J. In vivo / In vitro Stem Cell Tracking
K. Expansion / Differentiation Services
1. Stem Cell Media Services
2. RNAi Services
L. Stem Cell Lines
M. Summary of Product Categories
A. Definition: Stem Cell Research Products
B. Experimental Approach
C. Stem Cell Research Products, Market Size Determination
D. Stem Cell Antibodies, Market Size Determination
E. Stem Cell Therapies, Market Size Determination
A. Breakdown of Research Segments by End-user Application
1. Basic Research
2. Applied Research
a. Autologous and Allogeneic Cell Therapy
b. Toxicology Screening for Drug Discovery and Development
B. Breakdown of Stem Cell Research by Cell Type
C. Emerging Areas for Stem Cell Products
1. Cord Blood Stem Cells
2. Dental Stem Cells
3. Induced Pluripotent Stem Cells (iPSCs)
D. Top Ten Most Influential People within Stem Cell Industry
A. Clinical Trial Data
B. Grant Analysis
C. Patent Analysis
D. Scientific Publication Rate Analysis
1. Historical Data
2. Future 5-Year Projections
3. Comparison of Stem Cell Research Frequency, by Cell Type
E. Sources of Stem Cell Funding
1. Federal
2. State
3. Private
A. Five-Year Market Forecasts
B. Future Considerations
1. Near-term (1-3yrs): Stem Cells as Tools for Drug Discovery
2. Short-term (3-5yrs): Therapies Involving Cord Blood and Adult Stem Cells
3. Long-Term (10yrs): Therapies involving hESCs
A. Survey Overview
B. Characterization of Market Survey Respondents
1. Geographic Distribution of Respondents
2. Respondent Breakdown by Industry Affiliation
3. Breakdown of Respondents by Duration of Stem Cell Research Activity
C. Survey Findings – General Scope
D. Survey Findings – Applied Stem Cell Research
E. Survey Findings – Comparison of Providers (Brand Preferences)
A. Top Research Institutions Performing Stem Cell Research
1. University of Wisconsin, including WARF, WiCell, and the WISC Bank
2. Johns Hopkins University
3. US National Institutes of Health (NIH)
4. California Institute for Regenerative Medicine
B. Events of Interest
APPENDIX A – Full List of Conditions Being Explored within Stem Cell Clinical Grants Trials (2014)
APPENDIX B – Full List of Stem Cell Conferences (2014)



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